粪菌移植促进老年斑秃患者头发再生及相好转黑

躁郁症、疣赤。整体病患的病况，排除了凋亡外分泌新功能偏低、胆汁酸释放出不良、肾脏败血症、菌株连续性大肠病以及抗生素系统连续性连续性咳嗽等病症，考虑该病患的咳嗽主要是由于排泄质生态系统松弛归因于[10-12]，因此，对病患进行时了6次个疗程的粪菌再生疗程。NADPH起源于一名22岁的肥胖症未有成年，芽孢裂解制备使用智能粪菌裂解系统完毕，再生除此以外使用大肠镜下置入TET管方式。

FMT 疗程后随访18个年末，最后一次随访于2018年11年末22日。病患的咳嗽在FMT后一个年末明显好转，大日后周内增大至每日1-2次，食欲强化，腹心痛、烦症形如不复体现发挥作用。躁郁症形如也备受益了强化，汉密尔顿焦虑症量表(HAM-D17)评价由30分回升13分。BMI上升至18.3 kg/m2，血清体内内急剧下回升38 g/L。感到惊讶的是，虽然FMT前后没有用作任何其他疗程疣赤的药物，但是，在FMT后的第四周随访时，病患调查报告却说他的疣赤处之后长三出来原先短发，而且慢慢地的一部分白短发慢慢变黑，。最后一次访视时，他的短发保持生长三(所示2)，同时颈部老人疣不复体现发挥作用(未有照片)。

讨论

我们调查报告一则有中的国老人病患，因为慢连续性咳嗽做FMT疗程后，咳嗽症形如备受益有效连续性强化的同时，疣赤处之后长三出了头发，并且原来的剑侠部分转回胡子，躁郁症形如强化，颈部老人疣不复体现发挥作用。我们推断，所有这些变化都与FMT后排泄质生物群的改变有关。排泄生态系统生理在病原咳嗽中的起着关键发挥作用[16,17]。使用FMT疗程疑为梭形如芽胞病原体系统连续性咳嗽，其抗菌甚至比不上本品或安慰剂[18]。除病原咳嗽外，排泄生态系统生理在非病原咳嗽中的也体现着举足轻重发挥作用[10-12]。一项双盲、随机、安慰剂对照、交叉一组、单中的心试验车研究成果结果显示[7]，做FMT疗程后，咳嗽型大肠易激整体征症形如明显强化。在东莞医科大学国立大学自建第一疗养院FMT疗程中的心，我们用作FMT疗程了40则有咳嗽病患，所有病患的症形如除此以外备受益了明显强化(数据库未有发表撰文)。在这个确诊中的，我们对一位非病原咳嗽的老人病人进行时了FMT疗程。在疗程更进一步中的，我们惊奇地掩蔽到他病症周围的头发不可逆的情形。

疣赤的医学分型之外疣片形如疣赤、全赤和普赤[19]。其确诊一组态之外以下几个心理因素:(1)基因突变:已断定62个基因参加疣赤的确诊一组态[19];(2)抗病毒应答:抗病毒耐备受的丧失以及随后长丝自身鼓吹应连续性诱发的鼓吹击被相信是疣赤的主要形如况[1,19,20];(3)其他心理因素:氧化应激和传染因子可随之而来抗病毒耐备受的损害，引发疣赤[19,20]。此外，心理应激有可能是疣赤频发和其发展的过重心理因素，但这一观点已为体现发挥作用争议[20-23]。

疣赤的疗程方式之外几个多方面。第一，局部运用于皮质激素。但该疗程不能抑制疣赤在其他各部位的频发[1,19]。其次，成果迅速的疣赤病患可通过四肢运用于皮质类固醇而获益[19,24,25]。但是在大多数理论上，只能持续连续性的用作来保持头频发长三[19]。第三，接触抗病毒疗法对疣片形如疣赤病患有效连续性，但对全赤和泛赤[19]病患作废，而且复发率高(62%)。这理论上只能针对原先靶点进行时原先、不够有效连续性的疗程干预。

近十年，多项研究成果却说明，排泄质生态系统生理在抗原皮炎、牛皮癣等病症的确诊中的体现举足轻重发挥作用[26-29]。然而疣赤与排泄质生态系统生理的彼此间已为待详述。疣赤有可能与其他自身抗病毒连续性病症，尤其是IBD[30]有关。一系列医学确诊刊文IBD病患消失病症情形[31-34]，但对其病症了解非常少。排泄质生态系统生理是IBD的主要确诊一组态之一[35-37]，排泄质生态系统生理有可能是疣赤和IBD共存的共同除此以外。维他命B7是一种水溶连续性维他命，主要仰赖排泄中的的菌株造成。病症是维他命B7缺失[38]的显出之一，而这种缺失是由多种心理因素引发的，之外IBD[39]。最近，Hayashi等[2]刊文了在缺失维他命B7的无菌血清中的频发病症情形，并伴有疙瘩酸菌的过度生长三。血清在说明维他命B7后头发不可逆的，獭疙瘩病原体总数增大，却说明赤发主要是由于排泄质生态系统生理，尤其是獭疙瘩病原体过度生长三，随之而来糖类[2]缺失归因于。因此，排泄质生态系统生理和疣赤彼此之间体现发挥作用密切这样一来联系。

由排泄芽孢造成的短链羧酸(SCFAs)通过调节调节连续性T细胞(regulatory T cells, Tregs)的总数和新功能，有助于确保[40]的抗病毒稳态，Tregs在疣赤的诱导中的体现关键发挥作用[3,30]。Borde等[3]推断，SCFAs中的的乙酯灶通过刺激G肽偶联备受体，诱导造成不够多的耐备受连续性tregs，保护措施长丝免备受抗病毒鼓吹击。他们掩蔽到，5只C3H/He J血清(一种自发频发疣赤的血清)中的，在乙酯疗程11周后头发不可逆的，Treg/CD4+比则有增加。然而，当他们再度重复这项研究成果时，并没有重演短发不可逆的的积极结果。由于排泄芽孢种类多种不同，仅通过包括一种SCFAs来确保但会排泄芽孢是不够的，或许是随之而来结果不确定的形如况。然而，排泄质生态系统生理和疣赤彼此之间的寻常这样一来联系可能体现发挥作用，并且确保一个肥胖症的排泄质生态系统生存环境，而不是理论上包括几种SCFAs，将在疗程疣赤中的体现不够有效连续性的发挥作用。

维他命D是我们日常素食中的的质量营养素之一，它能确保体液中的钙和砷的但会高水平。维他命D通过活化复合物Cyp27B1[42]转化为1,25(OH)2D3的活连续性形式来体现其病理学新功能。1,25(OH)2D3通过融合维他命D备受体(VDR)从而使其保持病理学活连续性[43]。日益多的证词却说明，1,25 (OH)2D3缺失与疣赤有关[44-46]，其中的VDR缺失在疣赤中的体现举足轻重发挥作用[47-49]。最近的一项研究成果却说明1,25(OH)2D3缺失随之而来排泄质生态系统生理，随之而来SCFAs造成[50]的增大。另一多方面，多项研究成果却说明VDR和Cyp27B1的表达备受排泄芽孢的管控[51-53]。因此，虽然1,25(OH)2D3与排泄芽孢彼此之间体现发挥作用双向彼此间，1,25(OH)2D3缺失与排泄芽孢松弛彼此之间有可能体现发挥作用双向彼此间[43]，但已为不可信哪一种一组态是疣赤确诊的主要形如况。

FMT被相信是一种确保安全有效连续性的确保排泄质生态系统松弛的方式，对鼓吹复发作的CDI、IBD、IBS、胃溃疡等带有较差的医学抗菌[54-57]。FMT确保排泄质生态系统的方法已为未有完全详述。Ooijevaar等[58]提出有可能体现发挥作用两种除此以外，即这样一来除此以外和间接除此以外。在这样一来除此以外中的，一些有益菌和营养这样一来随着FMT河运，与病原菌恶连续性竞争，说明缺失的营养，这一更进一步与细胞内毫无彼此间。在间接除此以外中的，与细胞内系统连续性心理因素，之外抗病毒调节和机械设备屏障新功能等有关。

FMT在许多病症中的的较差的医学抗菌为疗程疣赤的包括了一种有可能的方式 [3,30]。2017年，Rebello等[59]刊文2则有病症CDI伴普发连续性病症病患在用作FMT疗程后头发不可逆的的则有子。与上述两则有确诊完全符合的是，单单疣片形如疣赤的老人病患在用作FMT疗程非病原咳嗽后消失了头发的长三期生长三(表1)。这些结果却说明，FMT可以通过说明排泄质生物群而有助于头发的不可逆的。肥胖症排泄质生物生存环境的确保有助于舰载机的抗病毒调节，强化营养的释放出和小分子，之外氨基酸/细胞内、糖类、SCFAs和维他命D，最终促进短发不可逆的。单单中的，老人病患经FMT后营养形如况有所强化，BMI和血清体内内除此以外略有急剧下降。遗憾的是，我们无法包括该病患在FMT前后的维他命B7和维他命D高水平,而这一资讯的拿到有可能有助于详述FMT随之而来头发不可逆的的一组态。

除了头发不可逆的之外，我们还断定该老人病患的白短发转回胡子的情形，而且脸上老人疣不复体现发挥作用。白短发转黑的一组态目前已为不具体。某些内脏抗原自身抗病毒连续性病症有可能参加了其中的，提示排泄芽孢有可能与白短发的转变成更进一步有关[60]。因此，该老人病患可以在确保排泄质生态系统生存环境平衡后白短发转回胡子。此外，由于排泄芽孢可以通过大肠-脑轴调节神经元和精神心理发挥作用[61,62]，病患在FMT后躁郁症形如也备受益强化。

总的来却说,尽管本则有子和Rebello等的医学报导[59]除此以外断定，FMT对疣赤除此以外有较差的医学抗菌，但仍只能进行大型的设计者较差的医学试验车，再进一步推测FMT疗程疣赤的医学抗菌。

Figure 1 Colonoscopy showing a normal colonic mucosa.

Figure 2 Hair regrowth on an elderly Chinese patient’s scalp after fecal microbiota transplantation. The patient’s scalp 1 mo (A), 4 mo (B), and 18 mo (C) after fecal microbiota transplantation, respectively.

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附件2 英文名称的摘要链接

干净芽孢再生（washed microbiota transplantation, WMT）

东莞医科大学国立大学自建第一疗养院消化内科自成立质生态系统疗程中的心以来，年末于2022年4年末30日，完毕WMT 6200 人次，其中的前十病种分别为：新开放连续性胃大肠病1693人次、儿童帕金森氏症1871人次、菌株连续性大肠病635人次、胃食管鼓吹流病420人次、非酒精连续性脂肪肝连续性胃溃疡178人次、胃癌失代偿期132人次、排泄芽孢生理369人次、心关节炎137人次、2型哮喘403人次以及皮肤类病症（银屑病、荨麻疹、皮疹皮炎、特应连续性皮炎和病症）120人次，除此以外拿到了情愿的医学抗菌。能用干净质生物群再生可以疗程本内脏（排泄质生物群这个类似于的内脏）结构及新功能损毁诱发的系统连续性病症，不仅在昆虫物理中的拿到了获得成功，而且在医学上也拿到了情愿的抗菌。

本中的心进行的WMT处于亚太地区主导地位，先后接收Rebiotix和Ferring研究成果所、北京阜外疗养院、岳皓市中的疗养院、成都中的医药国立大学自建疗养院、南方医科国立大学自建珠江疗养院等25家疗养院参观及进修自学，并对其进行时医学干净芽孢再生指导工作，使其获得成功建立了芽孢再生医学运用于与研究成果基地，同时作为周围救援队中的心，向救援队合作为单位中的文系自建第一疗养院、广州医科国立大学第一自建疗养院、广州医科国立大学第二自建疗养院、暨南国立大学自建东亚红十字会疗养院、锡林郭勒盟鄂温克旗疗养院等12个为单位进行时了干净芽孢再生救援队工作，并备受益了相鼓吹的赞誉。

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